Pronunciation: IN-su-lin LIS-pro
Generic Name: Insulin Lispro Protamine/Insulin Lispro
Brand Name: Examples include Humalog Mix 75/25 and Humalog Mix 50/50
Insulin Lispro Protamine/Insulin Lispro Pens are used for:
Treating diabetes mellitus.
Insulin Lispro Protamine/Insulin Lispro Pens are a combination of an intermediate-acting and a fast-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.
Do NOT use Insulin Lispro Protamine/Insulin Lispro Pens if:
- you are allergic to any ingredient in Insulin Lispro Protamine/Insulin Lispro Pens
- you are having an episode of low blood sugar
Contact your doctor or health care provider right away if any of these apply to you.
Before using Insulin Lispro Protamine/Insulin Lispro Pens:
Some medical conditions may interact with Insulin Lispro Protamine/Insulin Lispro Pens. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you drink alcoholic beverages or smoke
- if you have kidney or liver problems; nerve problems; adrenal, pituitary or thyroid problems; or diabetic ketoacidosis
- if you use 3 or more insulin injections per day
- if you are fasting, have high blood sodium levels, or are on a low salt diet
Some MEDICINES MAY INTERACT with Insulin Lispro Protamine/Insulin Lispro Pens. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Beta-blockers (eg, propranolol), clonidine, guanethidine, lithium, or reserpine because they may increase the risk of high or low blood sugar or may hide the signs and symptoms of low blood sugar, if it occurs
- Angiotensin-converting (ACE) inhibitors (eg, enalapril), disopyramide, fenfluramine, fibrates (eg, clofibrate, gemfibrozil), fluoxetine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), oral medicine for diabetes (eg, glipizide, metformin, nateglinide), pentamidine, propoxyphene, salicylates (eg, aspirin), somatostatin analogs (eg, octreotide), or sulfonamide antibiotics (eg, sulfamethoxazole) because the risk of low blood sugar may be increased
- Corticosteroids (eg, prednisone), danazol, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, chlorpromazine), progesterones (eg, medroxyprogesterone), somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid hormones (eg, levothyroxine) because they may decrease Insulin Lispro Protamine/Insulin Lispro Pens's effectiveness, resulting in high blood sugar
This may not be a complete list of all interactions that may occur. Ask your health care provider if Insulin Lispro Protamine/Insulin Lispro Pens may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Insulin Lispro Protamine/Insulin Lispro Pens:
Use Insulin Lispro Protamine/Insulin Lispro Pens as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Insulin Lispro Protamine/Insulin Lispro Pens. Talk to your pharmacist if you have questions about this information.
- Use Insulin Lispro Protamine/Insulin Lispro Pens within 15 minutes before a meal, unless directed otherwise by your doctor.
- If you will be using Insulin Lispro Protamine/Insulin Lispro Pens at home, a health care provider will teach you how to use it. Be sure you understand how to use Insulin Lispro Protamine/Insulin Lispro Pens. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Carefully rotate the vial or container as directed before each injection. This will ensure that the contents are evenly mixed. This combination insulin should look uniformly cloudy or milky.
- Do not use Insulin Lispro Protamine/Insulin Lispro Pens if it contains particles or clumps, is discolored, or if the vial or container is cracked or damaged.
- Do NOT dilute Insulin Lispro Protamine/Insulin Lispro Pens or mix it with other insulin. Do NOT use it in an insulin pump.
- Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle.
- Injection sites within an injection area (abdomen, thigh, upper arm) must be rotated from one injection to the next.
- Be sure you have purchased the correct insulin. Insulin comes in a variety of containers, including vials, cartridges, and pens. Make sure that you understand how to properly measure and prepare your dose. If you have any questions about measuring and preparing your dose, contact your doctor or pharmacist for information.
- Insulin Lispro Protamine/Insulin Lispro Pens begins lowering blood sugar within minutes after an injection. The effect may last for up to 24 hours.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- It is very important to follow your insulin regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you should ever miss a dose of insulin.
Ask your health care provider any questions you may have about how to use Insulin Lispro Protamine/Insulin Lispro Pens.
Important safety information:
- Insulin Lispro Protamine/Insulin Lispro Pens may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Insulin Lispro Protamine/Insulin Lispro Pens with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol without discussing it with your doctor. Drinking alcohol may increase the risk of developing high or low blood sugar.
- Do not use more than the recommended dose, use Insulin Lispro Protamine/Insulin Lispro Pens more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor.
- Any change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose.
- Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you will still require insulin. You and your doctor should establish a sick day plan to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed.
- Tell your doctor or dentist that you take Insulin Lispro Protamine/Insulin Lispro Pens before you receive any medical or dental care, emergency care, or surgery.
- If you will be traveling across time zones, consult your doctor concerning adjustments in your insulin schedule.
- Carry an ID card at all times that says you have diabetes.
- An insulin reaction resulting from low blood sugar levels (hypoglycemia) may occur if you take too much insulin, skip a meal, or exercise too much. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- Developing a fever or infection, eating significantly more than prescribed, or missing your dose of insulin may cause high blood sugar (hyperglycemia). High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If not treated, loss of consciousness, coma, or death may occur. If these symptoms occur, tell your doctor right away.
- Check with your doctor if you notice a depression in the skin or skin thickening at the injection site. You may need to change your injection technique.
- Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Insulin Lispro Protamine/Insulin Lispro Pens.
- Lab tests, including fasting blood glucose levels and hemoglobin A1c levels, may be performed while you use Insulin Lispro Protamine/Insulin Lispro Pens. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Insulin Lispro Protamine/Insulin Lispro Pens with caution in the ELDERLY; if low blood sugar occurs, it may be more difficult to recognize in these patients.
- Insulin Lispro Protamine/Insulin Lispro Pens should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Insulin Lispro Protamine/Insulin Lispro Pens while you are pregnant. It is not known if Insulin Lispro Protamine/Insulin Lispro Pens are found in breast milk. If you are or will be breast-feeding while you use Insulin Lispro Protamine/Insulin Lispro Pens, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Insulin Lispro Protamine/Insulin Lispro Pens:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Redness, swelling, itching, or mild pain at the injection site.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; slurred speech; swelling; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center or emergency room immediately. Symptoms may include chills; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; nervousness; seizures; shakiness; sweating; tremor; vision changes; weakness.
Proper storage of Insulin Lispro Protamine/Insulin Lispro Pens:
VIALS: Store new (unopened) vials in a refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze Insulin Lispro Protamine/Insulin Lispro Pens. Store used (open) vials either in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). If refrigeration is not possible, store at room temperature, below 86 degrees F (30 degrees C). Store away from heat and light. If Insulin Lispro Protamine/Insulin Lispro Pens has been frozen or overheated, throw it away. Throw away unrefrigerated or opened vials after 28 days, even if they still contain medicine.
PENS: Store new (unopened) pens in a refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze Insulin Lispro Protamine/Insulin Lispro Pens. Store used (open) pens at room temperature, below 86 degrees F (30 degrees C). Do NOT store used (open) pens in the refrigerator. Store away from heat and light. If Insulin Lispro Protamine/Insulin Lispro Pens has been frozen or overheated, throw it away. Throw away unrefrigerated or used pens after 10 days, even if they still contain medicine.
Do not leave Insulin Lispro Protamine/Insulin Lispro Pens in a car on a warm or sunny day. Do not use Insulin Lispro Protamine/Insulin Lispro Pens after the expiration date stamped on the label. Keep Insulin Lispro Protamine/Insulin Lispro Pens, as well as syringes and needles, out of the reach of children and away from pets.
General information:
- If you have any questions about Insulin Lispro Protamine/Insulin Lispro Pens, please talk with your doctor, pharmacist, or other health care provider.
- Insulin Lispro Protamine/Insulin Lispro Pens are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Insulin Lispro Protamine/Insulin Lispro Pens. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Insulin Lispro Protamine/Insulin Lispro resources
- Insulin Lispro Protamine/Insulin Lispro Use in Pregnancy & Breastfeeding
- Insulin Lispro Protamine/Insulin Lispro Drug Interactions
- Insulin Lispro Protamine/Insulin Lispro Support Group
- 1 Review for Insulin Lispro Protamine/Insulin Lispro - Add your own review/rating
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